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There were 66 businesses with addresses in St. Clair County zip codes that had between 50 and 99 employees in 2017, according to County Business Patterns (CBP) statistics provided by the United States Census Bureau.

CBP data indicates that there were 3,142 total businesses in St. Clair County zip codes.

The following table gives a breakdown of businesses in St. Clair County by total employees in 2017.

Total employees	Total businesses
0 to 4	1,606
5 to 9	656
10 to 19	440
20 to 49	265
50 to 99	66
100 to 249	50
250 to 499	12
more than 500	0-2