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There were 261 businesses in St. Clair County with between 20 and 49 employees in 2019, according to County Business Patterns (CBP) statistics provided by the United States Census Bureau.

CBP data indicates there were 3,089 total businesses in St. Clair County.

The following table gives a breakdown of businesses in St. Clair County by total employees in 2019.

Total employees	Total businesses
0 to 4	1,534
5 to 9	672
10 to 19	455
20 to 49	261
50 to 99	68
100 to 249	51
250 to 499	3
more than 500	0-2