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There were 55 businesses in Tuscola County with between 20 and 49 employees in 2019, according to County Business Patterns (CBP) statistics provided by the United States Census Bureau.

CBP data indicates there were 880 total businesses in Tuscola County.

The following table gives a breakdown of businesses in Tuscola County by total employees in 2019.

Total employees	Total businesses
0 to 4	472
5 to 9	197
10 to 19	97
20 to 49	55
50 to 99	15
100 to 249	4
250 to 499	3
more than 500	0-2